By Harris Goldstein, M.D., director, Einstein-Montefiore Center for AIDS Research, professor of pediatrics and microbiology & immunology and the Charles Michael Chair in Autoimmune Diseases, delivers a mini-course that provides a comprehensive overview in basic immunology for graduate and medical students and for anyone interested in understanding how the immune system works.
This mini-course was organized by the KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH) at the Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa to provide Sub-Saharan students, research trainees and HIV and TB investigators with a comprehensive course in immunology. (January 2010).
A bacterium (MRSA, yellow) being ingested by an immune cell (Neutrophil, purple)
|Subdivisions||Immunogenetics, Clinical, Molecular, Cellular, Humoral|
|Significant diseases||Immune disorder, Hypersensitivity, Autoimmune disease, Immunodeficiency|
|Significant tests||Immunoprecipitation, Immunoassay, Agglutination, Serology|
Immunology is a branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in several disciplines of science, and as such is further divided.
Even before the concept of immunity (from immunis, Latin for "exempt") was developed, numerous early physicians characterized organs that would later prove to be part of the immune system. The key primary lymphoid organs of the immune system are the thymus and bone marrow, and secondary lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and skin and liver. When health conditions warrant, immune system organs including the thymus, spleen, portions of bone marrow, lymph nodes and secondary lymphatic tissues can be surgically excised for examination while patients are still alive.
Many components of the immune system are actually cellular in nature and not associated with any specific organ but rather are embedded or circulating in various tissues located throughout the body.
- 1 Classical immunology
- 2 Clinical immunology
- 3 Developmental immunology
- 4 Immunotherapy
- 5 Diagnostic immunology
- 6 Cancer immunology
- 7 Reproductive immunology
- 8 Theoretical immunology
- 9 Immunologist
- 10 Immunology career
- 11 See also
- 12 Notes and references
- 13 External links
Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory.
The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system, and acquired or adaptive immune system of vertebrates, the latter of which is further divided into humoral and cellular components.
The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells (B lymphocytes). Antigens are defined as anything that elicits generation of antibodies, hence they are Antibody Generators. Immunology itself rests on an understanding of the properties of these two biological entities. However, equally important is the cellular response, which can not only kill infected cells in its own right, but is also crucial in controlling the antibody response. Put simply, both systems are highly interdependent.
In the 21st century, immunology has broadened its horizons with much research being performed in the more specialized niches of immunology. This includes the immunological function of cells, organs and systems not normally associated with the immune system, as well as the function of the immune system outside classical models of immunity (Yemeserach 2010).
Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features.
The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency, in which parts of the immune system fail to provide an adequate response (examples include chronic granulomatous disease and primary immune diseases), and autoimmunity, in which the immune system attacks its own host's body (examples include systemic lupus erythematosus, rheumatoid arthritis, Hashimoto's disease and myasthenia gravis). Other immune system disorders include different hypersensitivities, in which the system responds inappropriately to harmless compounds (asthma and other allergies) or responds too intensely.
The most well-known disease that affects the immune system itself is AIDS, caused by HIV. AIDS is an immunodeficiency characterized by the lack of CD4+ ("helper") T cells, dendritic cells and macrophages, which are destroyed by HIV.
Clinical immunologists also study ways to prevent transplant rejection, in which the immune system attempts to destroy allografts.
The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborns phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early in gestation but are not fully active.
Maternal factors also play a role in the body’s immune response. At birth most of the immunoglobulin is present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Although some IgA is provided in breast milk. These passively acquired antibodies can protect the newborn up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. By 6–9 months after birth, a child’s immune system begins to respond more strongly to glycoproteins. Not until 12–24 months of age is there a marked improvement in the body’s response to polysaccharides. This can be the reason for the specific time frames found in vaccination schedules.
During adolescence the human body undergoes several physical, physiological and immunological changes. These changes are started and mediated by different hormones. Depending on the sex either testosterone or 17-β-oestradiol, act on male and female bodies accordingly, start acting at ages of 12 and 10 years.
There is evidence that these steroids act directly not only on the primary and secondary sexual characteristics, but also have an effect on the development and regulation of the immune system.
There is an increased risk in developing autoimmunity for pubescent and post pubescent females and males. There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system.
The female sex hormone 17-β-oestradiol has been shown to regulate the level of immunological response. Similarly, some male androgens, like testosterone, seem to suppress the stress response to infection; but other androgens like DHEA have the opposite effect, as it increases the immune response instead of down playing it. As in females, the male sex hormones seem to have more control of the immune system during puberty and the time right after than in fully developed adults. Other than hormonal changes physical changes like the involution of the Thymus during puberty will also affect the immunological response of the subject or patient.
The use of immune system components to treat a disease or disorder is known as immunotherapy. Immunotherapy is most commonly used in the context of the treatment of cancers together with chemotherapy (drugs) and radiotherapy (radiation). However, immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases.
The specificity of the bond between antibody and antigen has made it an excellent tool in the detection of substances in a variety of diagnostic techniques. Antibodies specific for a desired antigen can be conjugated with a radiolabel, fluorescent label, or color-forming enzyme and are used as a "probe" to detect it. However, the similarity between some antigens can lead to false positives and other errors in such tests by antibodies cross-reacting with antigens that aren't exact matches.
The study of the interaction of the immune system with cancer cells can lead to diagnostic tests and therapies with which to find and fight cancer.
This area of the immunology is devoted to the study of immunological aspects of the reproductive process including fetus acceptance. The term has also been used by fertility clinics to address fertility problems, recurrent miscarriages, premature deliveries, and dangerous complications such as pre-eclampsia.
Immunology is strongly experimental in everyday practice, but it is also characterized by an ongoing theoretical attitude. Many theories have been suggested in immunology from the end of the nineteenth century up to the present time. The end of the 19th century and the beginning of the 20th century saw the fight of the "cellular" and the "humoral" theories of immunity. According to the cellular theory of immunity, represented in particular by Elie Metchnikoff, it was cells, and more precisely phagocytes, that were responsible for immune responses. In contrast, the humoral theory of immunity, held, among others, by Robert Koch and Emil von Behring, stated that the active immune agents were soluble components (molecules) found in the organism’s “humors”, and not cells, In the mid-1950s, Burnet, inspired by a suggestion made by Niels Jerne, formulated the clonal selection theory (CST) of immunity. On the basis of the CST, Burnet developed a theory of how an immune response is triggered according to the self-nonself distinction: "self" constituents (i.e., constituents of the body) do not trigger destructive immune responses, while "nonself" entities (be they pathogens or an allograft) trigger a destructive immune response. The theory was later modified to reflect new discoveries having to do with histocompatibility or the complex "two-signal" activation of T cells. The self-nonself theory of immunity and the self-nonself vocabulary have been criticized, but they are still very influential, More recently, several theoretical frameworks have been suggested in immunology, including "autopoietic" views, "cognitive immune" views, the "danger" theory, and the "discontinuity" theory. In recent years, the danger theory, suggested by Polly Matzinger and colleagues, has been very influential and has aroused many comments and discussions.
|Science, laboratory, medicine|
|Doctor of Philosophy, Doctor of Medicine, Doctor of Osteopathic Medicine|
|Physician, Research scientist|
According to the American Academy of Allergy, Asthma, and Immunology (AAAAI), "an immunologist is a research scientist who investigates the immune system of vertebrates (including the human immune system). Immunologists include research scientists (Ph.D.) who work in laboratories. Immunologists also include physicians who, for example, treat patients with immune system disorders. Some immunologists are physician-scientists who combine laboratory research with patient care."
Bioscience is the overall major in which undergraduate students who are interested in general well-being take in college. Immunology is a branch of Bioscience for undergraduate programs but the major gets specified as students move on for graduate program in immunology. The aim of immunology is to study the health of humans and animals through effective yet consistent research, (AAAAI, 2013). The most important thing about being immunologists is the research because it is the biggest portion of their jobs.
Most graduate immunology schools follow the AAI courses immunology which are offered throughout numerous schools in the U.S. For example, in New York State, there are several universities that offer the AAI courses immunology: Albany Medical College, Cornell University, Mount Sinai School of Medicine, New York University Langone Medical Center, University at Albany (SUNY), University at Buffalo (SUNY), University of Rochester Medical Center and Upstate Medical University (SUNY). The AAI immunology courses include an Introductory Course and an Advance Course. The Introductory Course is a course that gives students an overview of the basics of immunology.
In addition, this Introductory Course gives students more information to complement general biology or science training. It also has two different parts: Part I is an introduction to the basic principles of immunology and Part II is a clinically-oriented lecture series. On the other hand, the Advanced Course is another course for those who are willing to expand or update their understanding of immunology. It is advised for students who want to attend the Advanced Course to have a background of the principles of immunology. Most schools require students to take electives in other to complete their degrees. The amount of years for a Master’s degree is two years of study followed by a Bachelor’s degree. For a Doctoral or Ph.D. program it is required to take two additional years of study 
The expectation of occupational growth in immunology is an increase of 36 percent from 2010 to 2020. The median annual wage was $76,700 in May 2010. However, the lowest 10 percent of immunologists earned less than $41,560, and the top 10 percent earned more than $142,800, (Bureau of Labor Statistics, 2013). The practice of immunology itself is not specified by the U.S. Department of Labor but it belongs to the practice of life science in general.
- History of immunology
- International Reviews of Immunology
- List of immunologists
- Outline of immunology
Notes and references
- Janeway's Immunobiology textbook Searchable free online version at the National Center for Biotechnology Information
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- Silverstein A (1989). A History of Immunology. New York: Academic Press.
- Tauber AI and Chernyak L (1991). Metchnikoff and the Origins of Immunology. New York: Oxford University Press.
- Tauber AI (1994). The Immune Self: Theory or Metaphor?. Cambridge: Cambridge University Press.
- Jerne NK (1955). "The natural selection theory of antibody formation". Proceedings of the National Academy of Sciences USA 41: 849–57.
- Burnet FM (1959). The Clonal Selection Theory of Acquired Immunity. Cambridge: Cambridge University Press.
- Burnet FM (1969). Cellular Immunology: Self and Notself. Cambridge: Cambridge University Press.
- Bretscher P, Cohn M (1970). "A theory of self-nonself discrimination". Science 169: 1042–49. doi:10.1126/science.169.3950.1042.
- Matzinger P (2002). "The danger model: A renewed sense of self". Science 296: 301–5. doi:10.1126/science.1071059.
- Pradeu (2012). The Limits of the Self: Immunology and Biological Identity. New York: Oxford University Press.
- Langman RE, Cohn M (2000). "A minimal model for the self-nonself discrimination: a return to the basics". Seminars in Immunology 12: 189–195.
- Clark WR (2008). In Defense of Self: How the Immune System Really Works. New York: Oxford University Press.
- Coutinho A et al (1984). "From an antigen-centered, clonal perspective of immune responses to an organism-centered network perspective of autonomous reactivity of self-referential immune systems". Immunological Reviews 79: 151–168.
- Irun C (2000). Tending Adam’s garden: Evolving the cognitive immune self. San Diego: Academic Press.
- Pradeu T, Jaeger S, Vivier E (2013). "The speed of change: towards a discontinuity theory of immunity?". Nature Reviews Immunology. 13(10): 764–769. doi:10.1038/nri3521.
- "Office of Science Education - LifeWorks - Immunologist". Retrieved 2009-09-10.
-  North Carolina Association for Biomedical Research, 2013.
-  American Association of Immunology, n.d.
-  The American Association of Immunologists, n.d.
-  Stanford School of Medicine.
- http://www.bls.gov/bls/confidentiality.htm Bureau of Labor Statistics, 2013, May 02.
- http://www.bls.gov/bls/confidentiality.htm Bureau of Labor Statistics, 2013.
|At Wikiversity you can learn more and teach others about Immunology at:
The Department of Immunology
- The Immunology Link, a rich resource for Immunology information
- American Academy of Allergy, Asthma & Immunology
- British Society for Immunology
- Annual Review of Immunology (journal)
- BMC: Immunology- BioMed Central:Immunology is an open access journal publishing original peer-reviewed research articles.
- journal home Nature Reviews Immunology
- The Immunology Database and Analysis Portal - an NIAID-funded database resource of reference and experiment data covering the entire immunology domain
- Current discussions on Immunology in a scientific community
- Federation of Clinical Immunology Societies - fostering interdisciplinary approaches to both understand and treat immune-based diseases
- Immunology Simplified—from AIDS to ZZZZZZ by Barb Bancroft
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